Fisher M, Muckle G, Lanphear B, Arbuckle TE, Braun JM, Zidek A, Vélez MP, Lupien N, Bastien S, Ashley-Martin J, Oulhote Y, Borghese MM, Walker M, Asztalos E, Bouchard MF, Linda B, Palmert MR, Morrison KM, Cummings EA, Khatchadourian K, Panagiotopoulos C, Glendon G, Shutt R, Abdul-Fatah A, Seal K, Fraser WD. Paediatric and Perinatal Epidemiology 2023 Nov;37(8):719-732. doi: 10.1111/ppe.13013
What did the researchers do:
The pan-Canadian MIREC study was established to determine whether maternal environmental chemical exposures were associated with adverse pregnancy outcomes in 2001 pregnant women. The MIREC-CD PLUS study followed this cohort with the goal of assessing the potential effects of prenatal exposures on early child growth and neurodevelopment. Families with children between the ages of 15 months and 5 years were invited to participate in MIREC-CD PLUS, which included two home visits: at the first visit we assessed child growth and collected blood and urine from the children and at the 2nd visit standardized neurodevelopment tests were conducted. Finally, moms were asked to complete an online maternal self-administered questionnaire about their child’s development and themselves.
What did they find:
Between April 2013 and March 2015 we collected child growth measures on over 800 children and blood (67%), and urine (81%) were collected from the majority of the children. We measured concentrations of a number of environmental chemicals in these specimens. Between 500-600 children completed in person visits for neurodevelopment assessments and close to 900 moms completed the self-administered questionnaire. As of January 2022, 19 publications have used data from MIREC-CD PLUS to study physical growth and neurodevelopment. Most publications have capitalized on the vast amount of chemical exposure information collected during pregnancy and at delivery.
What does this mean:
Data collection for the MIREC-CD PLUS study is complete and analysis of the data continues examining prenatal exposure to existing and emerging chemicals of concern, both independently and as mixtures. The information gathered in this study will help Health Canada fill important knowledge gaps in the risk of chemical exposures on child growth and neurodevelopment.
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